example metakb evidence line; moa assertion contained in larger metakb aggregation w/ normalized proposition entities

metakb_moa_example_20260224.json

{
  "id": "metakb.assertion:8sjz1xj3a0Qjds5cNM47i0dSeSaTy4jw",
  "type": "Statement",
  "specifiedBy": {
    "id": "metakb.method:2026",
    "type": "Method",
    "name": "MetaKB (2026)",
    "reportedIn": {
      "type": "Document",
      "name": "Wagnerds et al",
      "title": "MetaKB v2",
      "doi": "10.1038/1111-1-1111-111-1111",
      "pmid": "9999999"
    }
  },
  "proposition": {
    "type": "VariantTherapeuticResponseProposition",
    "subjectVariant": {
      "id": "metakb.cv:PSQ.VA.D6NzpWXKqBnbcZZrXNSXj4tMUwROKbsQ",
      "type": "CategoricalVariant",
      "name": "tmp name",
      "constraints": [
        {
          "type": "DefiningAlleleConstraint",
          "allele": {
            "id": "ga4gh:VA.D6NzpWXKqBnbcZZrXNSXj4tMUwROKbsQ",
            "type": "Allele",
            "digest": "D6NzpWXKqBnbcZZrXNSXj4tMUwROKbsQ",
            "location": {
              "id": "ga4gh:SL.jGElwyBPYNWI-BkFFHKfgLJynt9zuNPs",
              "type": "SequenceLocation",
              "digest": "jGElwyBPYNWI-BkFFHKfgLJynt9zuNPs",
              "sequenceReference": {
                "type": "SequenceReference",
                "refgetAccession": "SQ.dmFigTG-0fY6I54swb7PoDuxCeT6O3Wg"
              },
              "start": 314,
              "end": 315,
              "sequence": "T"
            },
            "state": {
              "type": "LiteralSequenceExpression",
              "sequence": "I"
            }
          },
          "relations": [
            {
              "primaryCoding": {
                "system": "ga4gh-gks-term:allele-relation",
                "code": "liftover_to"
              }
            },
            {
              "primaryCoding": {
                "system": "http://www.sequenceontology.org",
                "code": "translation_of"
              }
            }
          ]
        }
      ]
    },
    "geneContextQualifier": {
      "id": "normalize.gene.hgnc:76",
      "conceptType": "Gene",
      "name": "ABL1",
      "primaryCoding": {
        "id": "hgnc:76",
        "system": "https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/",
        "code": "HGNC:76"
      }
    },
    "predicate": "predictsResistanceTo",
    "objectTherapeutic": {
      "id": "normalize.therapy.rxcui:282388",
      "conceptType": "Therapy",
      "name": "imatinib",
      "primaryCoding": {
        "id": "rxcui:282388",
        "system": "https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=",
        "code": "282388"
      }
    },
    "conditionQualifier": {
      "id": "normalize.disease.ncit:C3174",
      "conceptType": "Disease",
      "name": "Chronic Myeloid Leukemia, BCR-ABL1 Positive",
      "primaryCoding": {
        "id": "ncit:C3174",
        "system": "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=",
        "code": "C3174"
      }
    }
  },
  "direction": "supports",
  "classification": {
    "id": "metakb.classification:1",
    "name": "tmp metakb tr classification",
    "primaryCoding": {
      "system": "AMP/ASCO/CAP (AAC) Guidelines, 2017",
      "code": "Tier I"
    }
  },
  "hasEvidenceLines": [
    {
      "type": "EvidenceLine",
      "hasEvidenceItems": [
        {
          "id": "moa.assertion:66",
          "type": "Statement",
          "description": "T315I mutant ABL1 in p210 BCR-ABL cells resulted in retained high levels of phosphotyrosine at increasing concentrations of inhibitor STI-571, whereas wildtype appropriately received inhibition.",
          "specifiedBy": {
            "id": "moa.method:2021",
            "type": "Method",
            "name": "MOAlmanac (2021)",
            "reportedIn": {
              "type": "Document",
              "name": "Reardon, B., Moore, N.D., Moore, N.S. et al.",
              "title": "Integrating molecular profiles into clinical frameworks through the Molecular Oncology Almanac to prospectively guide precision oncology",
              "doi": "10.1038/s43018-021-00243-3",
              "pmid": "35121878"
            }
          },
          "reportedIn": [
            {
              "id": "moa.source:45",
              "type": "Document",
              "extensions": [
                {
                  "name": "source_type",
                  "value": "Journal"
                }
              ],
              "title": "Gorre, Mercedes E., et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293.5531 (2001): 876-880.",
              "urls": [
                "https://doi.org/10.1126/science.1062538"
              ],
              "doi": "10.1126/science.1062538",
              "pmid": "11423618"
            }
          ],
          "proposition": {
            "type": "VariantTherapeuticResponseProposition",
            "subjectVariant": {
              "id": "moa.variant:66",
              "type": "CategoricalVariant",
              "name": "ABL1 T315I",
              "extensions": [
                {
                  "name": "moa_representative_coordinate",
                  "value": {
                    "chromosome": "9",
                    "start_position": "133748283",
                    "end_position": "133748283",
                    "reference_allele": "C",
                    "alternate_allele": "T",
                    "cdna_change": "c.944C>T",
                    "protein_change": "p.T315I",
                    "exon": "5"
                  }
                },
                {
                  "name": "moa_feature_type",
                  "value": "somatic_variant"
                },
                {
                  "name": "moa_variant_annotation",
                  "value": "Missense"
                }
              ],
              "mappings": [
                {
                  "coding": {
                    "system": "https://www.ncbi.nlm.nih.gov/snp/",
                    "code": "rs121913459"
                  },
                  "relation": "relatedMatch"
                }
              ]
            },
            "geneContextQualifier": {
              "id": "moa.gene:ABL1",
              "name": "ABL1"
            },
            "predicate": "predictsResistanceTo",
            "objectTherapeutic": {
              "id": "moa.drug:Imatinib",
              "extensions": [
                {
                  "name": "moa_therapy_type",
                  "value": "Targeted therapy"
                }
              ],
              "conceptType": "Drug",
              "name": "Imatinib"
            },
            "conditionQualifier": {
              "id": "moa.disease:Chronic Myelogenous Leukemia",
              "conceptType": "Disease",
              "name": "Chronic Myelogenous Leukemia",
              "mappings": [
                {
                  "coding": {
                    "id": "oncotree:CML",
                    "name": "Chronic Myelogenous Leukemia",
                    "system": "https://oncotree.mskcc.org/?version=oncotree_latest_stable&field=CODE&search=",
                    "code": "CML"
                  },
                  "relation": "exactMatch"
                }
              ]
            }
          },
          "direction": "supports",
          "strength": {
            "primaryCoding": {
              "system": "https://moalmanac.org/about",
              "code": "Preclinical evidence"
            },
            "mappings": [
              {
                "coding": {
                  "name": "preclinical evidence",
                  "system": "https://go.osu.edu/evidence-codes",
                  "code": "e000009"
                },
                "relation": "exactMatch"
              }
            ]
          }
        }
      ],
      "directionOfEvidenceProvided": "supports"
    }
  ]
}