metakb_assertion_ingest_fails.txt

civic.eid:3811 can be loaded.
civic.eid:229 can be loaded.
civic.eid:4291 can be loaded.
civic.eid:4290 can be loaded.
civic.eid:4285 can be loaded.
civic.eid:4265 can be loaded.
civic.eid:885 can be loaded.
civic.eid:2994 can be loaded.
civic.aid:5 can be loaded.
civic.eid:2621 can be loaded.
civic.eid:229 can be loaded.
civic.eid:1665 can be loaded.
civic.eid:2634 can be loaded.
civic.eid:276 can be loaded.
civic.eid:3811 can be loaded.
civic.aid:105 can be loaded.
civic.eid:2997 can be loaded.
civic.eid:2629 can be loaded.
civic.eid:982 can be loaded.
civic.eid:968 can be loaded.
civic.eid:883 can be loaded.
civic.eid:879 can be loaded.
civic.aid:6 can be loaded.
civic.eid:7159 could not be loaded because subject variant object lacks constraints: id='civic.mpid:395' type='CategoricalVariant' name='BRAF Mutation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=166.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000288602.6', 'chromosome': '7', 'start': 140453136, 'stop': 140481403, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001564', 'name': 'gene_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001564'}, {'id': 'SO:0002053', 'name': 'gain_of_function_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0002053'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:399', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='399'), iris=None), relation='exactMatch')]
civic.aid:20 could not be loaded because civic.eid:7159 is not supported
civic.eid:7158 could not be loaded because subject variant object lacks constraints: id='civic.mpid:395' type='CategoricalVariant' name='BRAF Mutation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=166.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000288602.6', 'chromosome': '7', 'start': 140453136, 'stop': 140481403, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001564', 'name': 'gene_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001564'}, {'id': 'SO:0002053', 'name': 'gain_of_function_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0002053'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:399', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='399'), iris=None), relation='exactMatch')]
civic.aid:20 could not be loaded because civic.eid:7158 is not supported
civic.eid:7157 can be loaded.
civic.eid:7156 can be loaded.
civic.eid:103 can be loaded.
civic.eid:1552 can be loaded.
civic.eid:8108 can be loaded.
civic.eid:8106 can be loaded.
civic.eid:7728 could not be loaded because subject variant object lacks constraints: id='civic.mpid:515' type='CategoricalVariant' name='FLT3 Mutation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=85.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28577411, 'stop': 28674729, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0002053', 'name': 'gain_of_function_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0002053'}, {'id': 'SO:0001576', 'name': 'transcript_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001576'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:519', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='519'), iris=None), relation='exactMatch')]
civic.aid:33 could not be loaded because civic.eid:7728 is not supported
civic.eid:7283 could not be loaded because subject variant object lacks constraints: id='civic.mpid:515' type='CategoricalVariant' name='FLT3 Mutation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=85.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28577411, 'stop': 28674729, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0002053', 'name': 'gain_of_function_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0002053'}, {'id': 'SO:0001576', 'name': 'transcript_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001576'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:519', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='519'), iris=None), relation='exactMatch')]
civic.aid:33 could not be loaded because civic.eid:7283 is not supported
civic.eid:8351 can be loaded.
civic.aid:33 could not be loaded because subject variant object lacks constraints: id='civic.mpid:433' type='CategoricalVariant' name='FLT3 D835' description=None aliases=['ASP835'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='expressions', value=[{'syntax': 'hgvs.g', 'value': 'NC_000013.10:g.28592642C>A'}], description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=46.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28592640, 'stop': 28592642, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001818', 'name': 'protein_altering_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001818'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:437', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='437'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16276'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16273'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16272'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='375972'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='375971'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='375973'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16274'), iris=None), relation='relatedMatch')]
civic.eid:3758 can be loaded.
civic.eid:6178 can be loaded.
civic.eid:6940 can be loaded.
civic.eid:6938 can be loaded.
civic.aid:7 can be loaded.
civic.eid:7283 could not be loaded because subject variant object lacks constraints: id='civic.mpid:515' type='CategoricalVariant' name='FLT3 Mutation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=85.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28577411, 'stop': 28674729, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0002053', 'name': 'gain_of_function_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0002053'}, {'id': 'SO:0001576', 'name': 'transcript_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001576'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:519', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='519'), iris=None), relation='exactMatch')]
civic.aid:38 could not be loaded because civic.eid:7283 is not supported
civic.eid:7728 could not be loaded because subject variant object lacks constraints: id='civic.mpid:515' type='CategoricalVariant' name='FLT3 Mutation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=85.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28577411, 'stop': 28674729, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0002053', 'name': 'gain_of_function_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0002053'}, {'id': 'SO:0001576', 'name': 'transcript_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001576'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:519', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='519'), iris=None), relation='exactMatch')]
civic.aid:38 could not be loaded because civic.eid:7728 is not supported
civic.eid:8924 could not be loaded because subject variant object lacks constraints: id='civic.mpid:55' type='CategoricalVariant' name='FLT3 ITD' description='FLT3-ITD (internal tandem duplications) frequently occur in patients with hematologic malignancies such as chronic myelogenous leukemia, acute myeloid leukemia (AML) and myelodysplastic syndrome, but particularly in cytogenetically normal AML (CN-AML). These duplication events disrupt the juxtamembrane domain of FLT3 and can be the result of a duplication of internal FLT3 sequence or other unrelated sequence resulting in an in-frame duplication event. The length of these duplications can vary widely which may have prognostic consequences, but this has not been conclusively determined. FLT3-ITD mutations overall have generally been associated with poor prognosis. Additional genes associated with CN-AML such as NPM1 may modulate the prognosis associated with this variant.' aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=448.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28608219, 'stop': 28608351, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001821', 'name': 'inframe_insertion', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001821'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:55', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='55'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16270'), iris=None), relation='relatedMatch')]
civic.aid:38 could not be loaded because civic.eid:8924 is not supported
civic.eid:8923 could not be loaded because subject variant object lacks constraints: id='civic.mpid:55' type='CategoricalVariant' name='FLT3 ITD' description='FLT3-ITD (internal tandem duplications) frequently occur in patients with hematologic malignancies such as chronic myelogenous leukemia, acute myeloid leukemia (AML) and myelodysplastic syndrome, but particularly in cytogenetically normal AML (CN-AML). These duplication events disrupt the juxtamembrane domain of FLT3 and can be the result of a duplication of internal FLT3 sequence or other unrelated sequence resulting in an in-frame duplication event. The length of these duplications can vary widely which may have prognostic consequences, but this has not been conclusively determined. FLT3-ITD mutations overall have generally been associated with poor prognosis. Additional genes associated with CN-AML such as NPM1 may modulate the prognosis associated with this variant.' aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=448.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28608219, 'stop': 28608351, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001821', 'name': 'inframe_insertion', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001821'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:55', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='55'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16270'), iris=None), relation='relatedMatch')]
civic.aid:38 could not be loaded because civic.eid:8923 is not supported
civic.aid:38 could not be loaded because subject variant object lacks constraints: id='civic.mpid:55' type='CategoricalVariant' name='FLT3 ITD' description='FLT3-ITD (internal tandem duplications) frequently occur in patients with hematologic malignancies such as chronic myelogenous leukemia, acute myeloid leukemia (AML) and myelodysplastic syndrome, but particularly in cytogenetically normal AML (CN-AML). These duplication events disrupt the juxtamembrane domain of FLT3 and can be the result of a duplication of internal FLT3 sequence or other unrelated sequence resulting in an in-frame duplication event. The length of these duplications can vary widely which may have prognostic consequences, but this has not been conclusively determined. FLT3-ITD mutations overall have generally been associated with poor prognosis. Additional genes associated with CN-AML such as NPM1 may modulate the prognosis associated with this variant.' aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=448.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000241453.7', 'chromosome': '13', 'start': 28608219, 'stop': 28608351, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001821', 'name': 'inframe_insertion', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001821'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:55', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='55'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='16270'), iris=None), relation='relatedMatch')]
civic.eid:10801 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.aid:80 could not be loaded because civic.eid:10801 is not supported
civic.eid:11424 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.aid:80 could not be loaded because civic.eid:11424 is not supported
civic.eid:11423 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.aid:80 could not be loaded because civic.eid:11423 is not supported
civic.aid:80 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.eid:10800 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.aid:95 could not be loaded because civic.eid:10800 is not supported
civic.eid:10887 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.aid:95 could not be loaded because civic.eid:10887 is not supported
civic.eid:11581 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.aid:95 could not be loaded because civic.eid:11581 is not supported
civic.aid:95 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4547' type='CategoricalVariant' name='BCOR ITD ' description=None aliases=['INTERNAL TANDEM DUPLICATION'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=165.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:1000173', 'name': 'tandem_duplication', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:1000173'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4527', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4527'), iris=None), relation='exactMatch')]
civic.eid:11775 could not be loaded because subject variant object lacks constraints: id='civic.mpid:5040' type='CategoricalVariant' name='MYB Truncation' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4882', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4882'), iris=None), relation='exactMatch')]
civic.aid:113 could not be loaded because civic.eid:11775 is not supported
civic.eid:11774 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.aid:113 could not be loaded because civic.eid:11774 is not supported
civic.aid:113 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.eid:11776 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.aid:114 could not be loaded because civic.eid:11776 is not supported
civic.eid:11777 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.aid:114 could not be loaded because civic.eid:11777 is not supported
civic.eid:11778 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.aid:114 could not be loaded because civic.eid:11778 is not supported
civic.eid:11790 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.aid:114 could not be loaded because civic.eid:11790 is not supported
civic.aid:114 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4218' type='CategoricalVariant' name='MYB Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=42.5, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4328', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4328'), iris=None), relation='exactMatch')]
civic.eid:12077 could not be loaded because subject variant object lacks constraints: id='civic.mpid:5187' type='CategoricalVariant' name='MN1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4993', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4993'), iris=None), relation='exactMatch')]
civic.aid:132 could not be loaded because civic.eid:12077 is not supported
civic.eid:12078 could not be loaded because subject variant object lacks constraints: id='civic.mpid:5187' type='CategoricalVariant' name='MN1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4993', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4993'), iris=None), relation='exactMatch')]
civic.aid:132 could not be loaded because civic.eid:12078 is not supported
civic.eid:12079 could not be loaded because subject variant object lacks constraints: id='civic.mpid:5187' type='CategoricalVariant' name='MN1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4993', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4993'), iris=None), relation='exactMatch')]
civic.aid:132 could not be loaded because civic.eid:12079 is not supported
civic.aid:132 could not be loaded because subject variant object lacks constraints: id='civic.mpid:5187' type='CategoricalVariant' name='MN1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4993', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4993'), iris=None), relation='exactMatch')]
civic.eid:1122 could not be loaded because subject variant object lacks constraints: id='civic.mpid:302' type='CategoricalVariant' name='ERBB2 Amplification' description='Her2 (ERBB2) amplifications are seen in up to 20% of breast cancers and were associated with aggressive disease and poor prognosis when discovered. Trastuzumab first found considerable success, and was approved for treatment, in HER2 positive metastatic breast cancer (MBC) which had progressed under chemotherapy. These metastatic cancers nonetheless progressed under trastuzumab, and other forms of therapy were studied for next line treatments, including tyrosine kinase inhibitors. Lapatinib, a reversible inhibitor of tyrosine kinase activity in ErbB1 and ErbB2, and afatinib, an irreversible inhibitor of all 4 ErbB forms were shown to have activity in trastuzumab-progressed HER2 MBC. Interestingly trastuzumab itself also turned out to remain effective in treatment of trastuzumab-progressed HER2 MBC. The LUX-Breast 1 trial compared a TKI-based treatment (afatinib) to a trastuzumab-based treatment of trastuzumab-progressed HER2 MBC, and the LUX-Breast 3 trial addressed TKI application in the context of HER2 MBC with difficult to treat brain metastases. In neither of these cases was the TKI more effective, making successful future replacement of trastuzumab-based therapy with a TKI in trastuzumab-progressed HER2 MBC seem unlikely. Instead, a potential role for TKIs in this disease context is revealed in preclinical work suggesting synergism between TKI and trastuzumab action, and clinical trials with lapatinib or afatinib combined with trastuzumab indicate that dual HER2 blockade may be an effective therapy. Dual antibody HER2 blockade with pertuzumab instead of TKI in HER2 MBC has also recently shown strong results in the CLEOPATRA trial. HER2 overexpression is targeted in neoadjuvant breast cancer treatment, and has also been successfully targeted in gastric cancer.' aliases=['OVEREXPRESSION'] extensions=[Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=891.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000269571.5', 'chromosome': '17', 'start': 37856333, 'stop': 37884915, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001889', 'name': 'transcript_amplification', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001889'}], description=None)] members=[] constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:306', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='306'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='N/A'), iris=None), relation='relatedMatch')]
civic.aid:2 could not be loaded because civic.eid:1122 is not supported
civic.eid:529 could not be loaded because subject variant object lacks constraints: id='civic.mpid:302' type='CategoricalVariant' name='ERBB2 Amplification' description='Her2 (ERBB2) amplifications are seen in up to 20% of breast cancers and were associated with aggressive disease and poor prognosis when discovered. Trastuzumab first found considerable success, and was approved for treatment, in HER2 positive metastatic breast cancer (MBC) which had progressed under chemotherapy. These metastatic cancers nonetheless progressed under trastuzumab, and other forms of therapy were studied for next line treatments, including tyrosine kinase inhibitors. Lapatinib, a reversible inhibitor of tyrosine kinase activity in ErbB1 and ErbB2, and afatinib, an irreversible inhibitor of all 4 ErbB forms were shown to have activity in trastuzumab-progressed HER2 MBC. Interestingly trastuzumab itself also turned out to remain effective in treatment of trastuzumab-progressed HER2 MBC. The LUX-Breast 1 trial compared a TKI-based treatment (afatinib) to a trastuzumab-based treatment of trastuzumab-progressed HER2 MBC, and the LUX-Breast 3 trial addressed TKI application in the context of HER2 MBC with difficult to treat brain metastases. In neither of these cases was the TKI more effective, making successful future replacement of trastuzumab-based therapy with a TKI in trastuzumab-progressed HER2 MBC seem unlikely. Instead, a potential role for TKIs in this disease context is revealed in preclinical work suggesting synergism between TKI and trastuzumab action, and clinical trials with lapatinib or afatinib combined with trastuzumab indicate that dual HER2 blockade may be an effective therapy. Dual antibody HER2 blockade with pertuzumab instead of TKI in HER2 MBC has also recently shown strong results in the CLEOPATRA trial. HER2 overexpression is targeted in neoadjuvant breast cancer treatment, and has also been successfully targeted in gastric cancer.' aliases=['OVEREXPRESSION'] extensions=[Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=891.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000269571.5', 'chromosome': '17', 'start': 37856333, 'stop': 37884915, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001889', 'name': 'transcript_amplification', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001889'}], description=None)] members=[] constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:306', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='306'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='N/A'), iris=None), relation='relatedMatch')]
civic.aid:2 could not be loaded because civic.eid:529 is not supported
civic.eid:528 could not be loaded because subject variant object lacks constraints: id='civic.mpid:302' type='CategoricalVariant' name='ERBB2 Amplification' description='Her2 (ERBB2) amplifications are seen in up to 20% of breast cancers and were associated with aggressive disease and poor prognosis when discovered. Trastuzumab first found considerable success, and was approved for treatment, in HER2 positive metastatic breast cancer (MBC) which had progressed under chemotherapy. These metastatic cancers nonetheless progressed under trastuzumab, and other forms of therapy were studied for next line treatments, including tyrosine kinase inhibitors. Lapatinib, a reversible inhibitor of tyrosine kinase activity in ErbB1 and ErbB2, and afatinib, an irreversible inhibitor of all 4 ErbB forms were shown to have activity in trastuzumab-progressed HER2 MBC. Interestingly trastuzumab itself also turned out to remain effective in treatment of trastuzumab-progressed HER2 MBC. The LUX-Breast 1 trial compared a TKI-based treatment (afatinib) to a trastuzumab-based treatment of trastuzumab-progressed HER2 MBC, and the LUX-Breast 3 trial addressed TKI application in the context of HER2 MBC with difficult to treat brain metastases. In neither of these cases was the TKI more effective, making successful future replacement of trastuzumab-based therapy with a TKI in trastuzumab-progressed HER2 MBC seem unlikely. Instead, a potential role for TKIs in this disease context is revealed in preclinical work suggesting synergism between TKI and trastuzumab action, and clinical trials with lapatinib or afatinib combined with trastuzumab indicate that dual HER2 blockade may be an effective therapy. Dual antibody HER2 blockade with pertuzumab instead of TKI in HER2 MBC has also recently shown strong results in the CLEOPATRA trial. HER2 overexpression is targeted in neoadjuvant breast cancer treatment, and has also been successfully targeted in gastric cancer.' aliases=['OVEREXPRESSION'] extensions=[Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=891.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000269571.5', 'chromosome': '17', 'start': 37856333, 'stop': 37884915, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001889', 'name': 'transcript_amplification', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001889'}], description=None)] members=[] constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:306', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='306'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='N/A'), iris=None), relation='relatedMatch')]
civic.aid:2 could not be loaded because civic.eid:528 is not supported
civic.aid:2 could not be loaded because subject variant object lacks constraints: id='civic.mpid:302' type='CategoricalVariant' name='ERBB2 Amplification' description='Her2 (ERBB2) amplifications are seen in up to 20% of breast cancers and were associated with aggressive disease and poor prognosis when discovered. Trastuzumab first found considerable success, and was approved for treatment, in HER2 positive metastatic breast cancer (MBC) which had progressed under chemotherapy. These metastatic cancers nonetheless progressed under trastuzumab, and other forms of therapy were studied for next line treatments, including tyrosine kinase inhibitors. Lapatinib, a reversible inhibitor of tyrosine kinase activity in ErbB1 and ErbB2, and afatinib, an irreversible inhibitor of all 4 ErbB forms were shown to have activity in trastuzumab-progressed HER2 MBC. Interestingly trastuzumab itself also turned out to remain effective in treatment of trastuzumab-progressed HER2 MBC. The LUX-Breast 1 trial compared a TKI-based treatment (afatinib) to a trastuzumab-based treatment of trastuzumab-progressed HER2 MBC, and the LUX-Breast 3 trial addressed TKI application in the context of HER2 MBC with difficult to treat brain metastases. In neither of these cases was the TKI more effective, making successful future replacement of trastuzumab-based therapy with a TKI in trastuzumab-progressed HER2 MBC seem unlikely. Instead, a potential role for TKIs in this disease context is revealed in preclinical work suggesting synergism between TKI and trastuzumab action, and clinical trials with lapatinib or afatinib combined with trastuzumab indicate that dual HER2 blockade may be an effective therapy. Dual antibody HER2 blockade with pertuzumab instead of TKI in HER2 MBC has also recently shown strong results in the CLEOPATRA trial. HER2 overexpression is targeted in neoadjuvant breast cancer treatment, and has also been successfully targeted in gastric cancer.' aliases=['OVEREXPRESSION'] extensions=[Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=891.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000269571.5', 'chromosome': '17', 'start': 37856333, 'stop': 37884915, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001889', 'name': 'transcript_amplification', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001889'}], description=None)] members=[] constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:306', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='306'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='N/A'), iris=None), relation='relatedMatch')]
civic.eid:6966 could not be loaded because subject variant object lacks constraints: id='civic.mpid:17' type='CategoricalVariant' name='BRAF V600' description='BRAF mutations of the valine 600 residue have been shown to be recurrent in many cancer types. Of the V600 mutations, V600E is the most widely researched. V600 mutations as a whole have been correlated to poorer prognosis in colorectal and papilarry thyroid cancers. V600 mutations have also been shown to confer sensitivity to the BRAF inhibitor dabrafenib. For a more detailed summary, click the individual mutations.' aliases=['VAL600'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=460.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000288602.6', 'chromosome': '7', 'start': 140453136, 'stop': 140453137, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001818', 'name': 'protein_altering_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001818'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:17', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='17'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='13961'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44815'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376288'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='40389'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376289'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44816'), iris=None), relation='relatedMatch')]
civic.aid:10 could not be loaded because civic.eid:6966 is not supported
civic.eid:6044 could not be loaded because subject variant object lacks constraints: id='civic.mpid:17' type='CategoricalVariant' name='BRAF V600' description='BRAF mutations of the valine 600 residue have been shown to be recurrent in many cancer types. Of the V600 mutations, V600E is the most widely researched. V600 mutations as a whole have been correlated to poorer prognosis in colorectal and papilarry thyroid cancers. V600 mutations have also been shown to confer sensitivity to the BRAF inhibitor dabrafenib. For a more detailed summary, click the individual mutations.' aliases=['VAL600'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=460.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000288602.6', 'chromosome': '7', 'start': 140453136, 'stop': 140453137, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001818', 'name': 'protein_altering_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001818'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:17', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='17'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='13961'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44815'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376288'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='40389'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376289'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44816'), iris=None), relation='relatedMatch')]
civic.aid:10 could not be loaded because civic.eid:6044 is not supported
civic.eid:1421 can be loaded.
civic.eid:6966 could not be loaded because subject variant object lacks constraints: id='civic.mpid:17' type='CategoricalVariant' name='BRAF V600' description='BRAF mutations of the valine 600 residue have been shown to be recurrent in many cancer types. Of the V600 mutations, V600E is the most widely researched. V600 mutations as a whole have been correlated to poorer prognosis in colorectal and papilarry thyroid cancers. V600 mutations have also been shown to confer sensitivity to the BRAF inhibitor dabrafenib. For a more detailed summary, click the individual mutations.' aliases=['VAL600'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=460.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000288602.6', 'chromosome': '7', 'start': 140453136, 'stop': 140453137, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001818', 'name': 'protein_altering_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001818'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:17', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='17'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='13961'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44815'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376288'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='40389'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376289'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44816'), iris=None), relation='relatedMatch')]
civic.aid:11 could not be loaded because civic.eid:6966 is not supported
civic.eid:6044 could not be loaded because subject variant object lacks constraints: id='civic.mpid:17' type='CategoricalVariant' name='BRAF V600' description='BRAF mutations of the valine 600 residue have been shown to be recurrent in many cancer types. Of the V600 mutations, V600E is the most widely researched. V600 mutations as a whole have been correlated to poorer prognosis in colorectal and papilarry thyroid cancers. V600 mutations have also been shown to confer sensitivity to the BRAF inhibitor dabrafenib. For a more detailed summary, click the individual mutations.' aliases=['VAL600'] extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=460.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'ensembl_version': 75, 'reference_build': 'GRCh37', 'representative_transcript': 'ENST00000288602.6', 'chromosome': '7', 'start': 140453136, 'stop': 140453137, 'type': 'coordinates'}, description=None), Extension(id=None, extensions=None, name='Variant types', value=[{'id': 'SO:0001818', 'name': 'protein_altering_variant', 'system': 'http://www.sequenceontology.org/browser/current_svn/term/', 'code': 'SO:0001818'}], description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:17', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='17'), iris=None), relation='exactMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='13961'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44815'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376288'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='40389'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='376289'), iris=None), relation='relatedMatch'), ConceptMapping(id=None, extensions=None, coding=Coding(id=None, extensions=None, name=None, system='https://www.ncbi.nlm.nih.gov/clinvar/variation/', systemVersion=None, code=code(root='44816'), iris=None), relation='relatedMatch')]
civic.aid:11 could not be loaded because civic.eid:6044 is not supported
civic.eid:6965 can be loaded.
civic.eid:4181 can be loaded.
civic.eid:6179 can be loaded.
civic.aid:13 can be loaded.
civic.eid:11519 can be loaded.
civic.eid:7290 can be loaded.
civic.eid:7291 can be loaded.
civic.aid:91 could not be loaded because condition failed to normalize: id='civic.did:3433' extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None)] conceptType='Disease' name='B-lymphoblastic Leukemia/lymphoma With PAX5 P80R' primaryCoding=None mappings=None
civic.eid:11779 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4878' type='CategoricalVariant' name='MYBL1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4743', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4743'), iris=None), relation='exactMatch')]
civic.aid:115 could not be loaded because civic.eid:11779 is not supported
civic.eid:11780 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4878' type='CategoricalVariant' name='MYBL1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4743', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4743'), iris=None), relation='exactMatch')]
civic.aid:115 could not be loaded because civic.eid:11780 is not supported
civic.eid:11781 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4878' type='CategoricalVariant' name='MYBL1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4743', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4743'), iris=None), relation='exactMatch')]
civic.aid:115 could not be loaded because civic.eid:11781 is not supported
civic.aid:115 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4878' type='CategoricalVariant' name='MYBL1 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4743', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4743'), iris=None), relation='exactMatch')]
civic.eid:12327 could not be loaded because subject variant object lacks constraints: id='civic.mpid:3527' type='CategoricalVariant' name='SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=15.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:3659', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='3659'), iris=None), relation='exactMatch')]
civic.aid:161 could not be loaded because civic.eid:12327 is not supported
civic.eid:12328 could not be loaded because subject variant object lacks constraints: id='civic.mpid:3527' type='CategoricalVariant' name='SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=15.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:3659', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='3659'), iris=None), relation='exactMatch')]
civic.aid:161 could not be loaded because civic.eid:12328 is not supported
civic.eid:12332 could not be loaded because subject variant object lacks constraints: id='civic.mpid:3527' type='CategoricalVariant' name='SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=15.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:3659', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='3659'), iris=None), relation='exactMatch')]
civic.aid:161 could not be loaded because civic.eid:12332 is not supported
civic.aid:161 could not be loaded because subject variant object lacks constraints: id='civic.mpid:3527' type='CategoricalVariant' name='SMARCB1 LOSS OF NUCLEAR PROTEIN EXPRESSION' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=15.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:3659', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='3659'), iris=None), relation='exactMatch')]
civic.eid:4846 can be loaded.
civic.eid:6955 can be loaded.
civic.aid:9 can be loaded.
civic.eid:11527 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4620' type='CategoricalVariant' name='FOXR2 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4575', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4575'), iris=None), relation='exactMatch')]
civic.aid:93 could not be loaded because civic.eid:11527 is not supported
civic.eid:11528 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4620' type='CategoricalVariant' name='FOXR2 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4575', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4575'), iris=None), relation='exactMatch')]
civic.aid:93 could not be loaded because civic.eid:11528 is not supported
civic.aid:93 could not be loaded because subject variant object lacks constraints: id='civic.mpid:4620' type='CategoricalVariant' name='FOXR2 Rearrangement' description=None aliases=None extensions=[Extension(id=None, extensions=None, name='vicc_normalizer_failure', value=True, description=None), Extension(id=None, extensions=None, name='CIViC Molecular Profile Score', value=40.0, description=None), Extension(id=None, extensions=None, name='CIViC representative coordinate', value={'type': 'coordinates'}, description=None)] members=None constraints=None mappings=[ConceptMapping(id=None, extensions=None, coding=Coding(id='civic.vid:4575', extensions=None, name=None, system='https://civicdb.org/variants/', systemVersion=None, code=code(root='4575'), iris=None), relation='exactMatch')]