Detects screenshots on MacOS and moves them to the trash, included launchd config too put this in ~/Library/LaunchAgents

delete_screenshots.py

from os import listdir, environ, rename
from os.path import isfile, join
from re import compile, search

regex = compile("Screen Shot \d{4}-\d{2}-\d{2} at \d{1,2}.\d{2}.\d{2} [AM PM]{2}")

def isScreenshot(f):
    return search(regex, f)

files = [f for f in listdir(environ['HOME'] + '/Desktop') if isfile(join(environ['HOME'] + '/Desktop', f))]
for f in files:
    if isScreenshot(f):
        rename(join(environ['HOME'] + '/Desktop', f), join(environ['HOME'] + '/.Trash', f))

job.plist

<!--- launchd plist: replace the ##PATH## with the path to your delete_screenshots.py, this will delete screenshots every 3 hours --->
<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE plist PUBLIC "-//Apple//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd">
<plist version="1.0">
<dict>
        <key>Label</key>
        <string>screenshot-cleaner</string>
        <key>ProgramArguments</key>
        <array>
                <string>/usr/bin/python</string>
                <string>##PATH##</string> <!-- replace ##PATH## with your location e.g. /Users/gsumpster/delete_screenshots.py -->
        </array>
        <key>RunAtLoad</key>
        <true/>
        <key>StartInterval</key>
        <integer>10800</integer> <!-- replace this with your desired interval in seconds, currently 3 hours -->
</dict>
</plist>