Debian or Kali Linux installed to as KVM (libvirtd) guests do not automatically have qemu-guest-agent or spice-vdagent installed. This will prevent seamless movement of the mouse cursor between the guest and host desktop in Virtual Machine Manager (requiring the use of a Ctrl-Alt to release the cursor from the guest window).
To cure this, install both qemu-guest-agent and spice-vdagent on each guest and reboot (the guests).
sudo apt install qemu-guest-agent
sudo apt install spice-vdagent
sudo apt install xserver-xorg-video-qxlFor Windows https://raphtlw.medium.com/how-to-set-up-a-kvm-qemu-windows-10-vm-ca1789411760
Virtio Drivers: https://fedorapeople.org/groups/virt/virtio-win/direct-downloads/stable-virtio/virtio-win.iso
Guest tool: https://www.spice-space.org/download.html
Currently running Kali GNU/Linux Rolling 2025.4 and it has all three packages installed in the QEMU appliance image.
However, if you install from the generic ISO image it's understandable that these packages are not installed since you could be running it on bare metal or any other hypervisor that would require other agents (VirtualBox, VMWare etc.).